A 36-year-old surgical nurse was stuck with a suture needle while assisting with emergent surgery of a patient who is human immunodefi ciency virus (HIV) positive. She saw blood in her glove and called the employee health offi ce for recommendations. Which of the following is false ? a. Initiation of postexposure prophylaxis with zidovudine in combination with lamivudine will signifi cantly decrease her risk of acquiring HIV. b. Postexposure prophylaxis should be continued if tolerated for 12 weeks. c. Use of 3 drugs should be considered if the surgical patient has known resistance to lamivudine. d. Th e risk of acquiring HIV from a needlestick injury is approximately 3 in 1,000 events. e. Postexposure prophylaxis is unlikely to be helpful if not started within 72 hours.

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